To test the existence of the salt bridge and stability Rocker Switch of the HIV-1 p17 matrix protein, an E12A (mutated at helix 1) was established to abolish possible electrostatic interactions.The chemical shift perturbation from the comparison between wild type and E12A suggested the existence of an electrostatic interaction in wild type between
Wenhui Pan, Mengyao Qin, Guoguang Zhang, Yueming Long, Wenyi Ruan, Jingtong Pan, Zushuai Wu, Tao Wan, Chuanbin Wu, Yuehong Xu Department of Pharmaceutics, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, People’s Republic of China Abstract: Tacrolimus (FK506), an effective immunosuppressant for treating inflammatory skin
Eclipse naevi are a kind of signature naevi that are mostly observed on trunks of adults and on scalps of children.As they can have some of the criteria for melanoma and can be difficult to follow Soft shell up especially when they are located on scalp, removal might be recommended frequently by dermatologists.However they are actually benign and t
Occlusion and its relationship to Orthopedic Accessories the function of the stomatognathic system have been widely studied in dentistry since many decades.This series of articles describe about occlusion in the complete denture, fixed partial denture, and implants.Part I and II of this articles series describe concepts and philosophies of occlusio
A budget proposal to stop the U.S.Centers for Disease Control and Prevention (CDC) funding in surveillance and research for mosquito-borne diseases such as dengue and West Nile virus has the potential to leave the country ill-prepared to handle new emerging diseases and manage existing ones.In order to demonstrate the consequences of Rocker Switch